In 2013, the American actress Angelina Jolie made a life-altering decision that fascinated the public and made the cover of Time magazine [1].  Based upon her family history and a genetic blood test for the BRCA1 gene, she was counseled that she had an 87% chance of developing breast cancer.  This led to her decision to undergo a preventive double mastectomy.  The Time article was titled “The Angelina Effect” and focused on the power of genomic medicine to guide clinical decision making.  A family history can be considered part of “clinical information” and would certainly increase the odds of developing breast cancer, but only the genomic test increased those odds such that a preventive procedure became a reasonable strategy.