Biopsy Decision

A biopsy decision, like any other medical decision, requires a good understanding of Risk vs Benefit.  The following video from Dr Mark Scholz should help clarify the issues for you:

So Your PSA is High, What Now?

Corresponding with above video - List of Quality MRI Centers

These articles should also be helpful - 

Infection Associated with Prostate Biopsy

Eleven Decisions Before Prostate Biopsy