Metastatic Prostate Cancer Treatment Case Study | Mark Scholz MD | AlexScholz | PCRI
In this video, PCRI's Alex asks Dr. Scholz about recent changes in the management of advanced prostate cancer patients. They discuss new treatments that are becoming available and how the validation of early, aggressive combination treatment protocols have achieved substantially better outcomes for metastatic patients in large Phase III clinical trials when compared to the previous standard of care which put men on hormone therapy indefinitely and then reserved stronger treatments like chemotherapy and second generation anti-androgens until the development of hormone resistance. Dr. Scholz also presents a case study of a man who was diagnosed with low-volume metastatic prostate cancer to the bone in 1996. He was treated with an early variation of those aggressive protocols and is still alive today in 2023. While it is unclear the extent to which these new methods will improve survival and quality of life for each and every patient, patients who are faced with a diagnosis of metastatic prostate cancer can at least feel optimistic that their chance of achieving favorable outcomes (remission, durable remission, and possibly even cure) are better than what contemporarily available statistics may suggest (since they are based on patients who were treated with older protocols).
0:07 Can you give a survey of the treatments available for bone metastases?
1:05 -- A Case study of a man diagnosed with limited bone metastasis in 1996. He was treated with an early version of the new aggressive protocols that are just now being validated by Phase III clinical trial. Despite less effective treatments available at the time, the patient is still alive today, in 2023.
3:15 How commonly do men with metastatic disease achieve remission?
4:53 How do the older chemotherapies used in the case study compare to contemporary chemotherapy like Taxotere?
7:44 Can a patient redo chemotherapy or radiation again if the cancer returns?
9:07 How accessible are these systematic treatments?
10:21 Are there any situations in which you would not want to use aggressive treatment on a metastatic patient?
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